Cytonus Therapeutics Inc. is a San Diego-based biotech company that has developed a vast platform of proprietary immunotherapeutic products to treat a wide range of medical conditions including cancers, infectious diseases, inflammatory diseases and cognitive disorders, and to improve patient outcomes. Its proprietary Cargocyte™ technologies are next-generation biomolecular delivery devices which have numerous medical applications across unmet therapeutic areas. Cargocytes™ are engineered to safely transport a multiplicity of therapeutic payloads into difficult-to-reach targeted tissues, and can be programmed to deliver selective, potent, and controllable “off-the-shelf” therapies. Cytonus’ vast platform of therapeutics and vaccines has the potential to improve the health and lives of people with life-threatening conditions.
Cytonus’ dual mission is to:
Cytonus’ platform technology is based on its proprietary CARGOCYTE™ bio-molecular delivery transporters. These biologic devices are engineered from enucleated cells and then programmed to carry and produce multiple therapeutic payloads in a precise, safe, and predictable manner. In more than 300 experiments conducted over the past five years, Cargocytes have demonstrated highly differentiated capabilities compared with other drug delivery solutions that are currently in today’s market. Among these numerous sources of differentiation are Cargocyte’s unique abilities to (i) actively and efficiently deliver powerful therapeutics directly into targeted cells by “homing” to targeted tissues, (ii) locate and activate the body’s immune system to attack infections, diseased tissues and cancer cells, and (iii) be manufactured at scale to enable the rapid and efficient deployment of life-saving therapeutics and vaccine preventions, to address the needs of healthcare systems to treat the world’s human populations.
| Key attributes for drug delivery | TIL | CAR-T | CARGOCYTE™ |
| Controllable | X | X | ✔ |
| Homogeneous Source | X | ✔ | ✔ |
| Unlimited Engineering | X | X | ✔ |
| “Off-the-shelf” | X | X | ✔ |
| Controllable Engraftment | X | X | ✔ |
| Safe after Engineering | X | X or ✔ | ✔ |
TIL- Tumor Infiltrating Lymphocyte
CAR-Chimeric Antigen Receptors
Time-lapse video of Lifeact-RFP hTERT MSCs and derived Cargocytes (red) migrating through 1 µm and 15µm constrictions inside a microfluidic device towards chemoattractant (FBS). The enucleated Cargocytes migrate faster through the small constrictions, likely due to the absence of the large/dense nucleus. The MSCs and Cargocytes were stained with nuclear dye Hoechst 33342 (blue). Video courtesy of J. Keys (Lammerding Lab, Cornell).
Cytonus’ vast platform technology uniquely positions us to become the Delivery Solution Partner for the World’s Leading Therapeutics Companies. We have entered strategic partnership discussions with pharma companies whose specific products will be enhanced with increased safety and effectiveness when packaged in a Cargocyte for delivery to targeted tissues. We believe these licensing and co-development commercial opportunities will add significant value for these strategic partners, and also translate into significant future potential returns for our company. In addition to serving as a Delivery Solution for other companies’ therapeutics, Cytonus is developing and commercializing its own proprietary pipeline of therapeutics and vaccine technologies. We believe the biotech industry will continue to be one of the most exciting sectors with many promising opportunities for future investment. Cytonus stands out among them for its vast platform that repeatedly demonstrates truly differentiated advantages.
Videos
Cytonus Therapeutics reveals new strategic partnership agreement with Austria-based Phoenestra
Cytonus Therapeutics to meet with the FDA in 2020 with its immuno-oncology platform technology
Press releases
Posters
Exhibited at ASCB/EMBO 2018, San Diego
Exhibited at AACR 2019, Atlanta
Exhibited at ASGCT 2019, Washington DC
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